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Whilst the opiate receptor relies on G protein coupling for signal transduction, this receptor was identified to make the most of arrestin activation for internalization from the receptor. Otherwise, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have
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Gene expression Evaluation revealed that ACKR3 is very expressed in various brain regions similar to important opioid action centers. Moreover, its expression concentrations are sometimes higher than These of classical opioid receptors, which further supports the physiological relevance of its n
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The interactions among the opioid peptides and classical receptors bring about a cascade of protein signaling